Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
DISCENTE: SATHIYABAMA RAJIV GANDHI
DATA: 12/12/2023
HORA: 14:00
LOCAL: http://meet.google.com/mmn-casr-xvf
TÍTULO: “PHYTOCHEMICAL, ANTI- HYPERALGESIC AND ANTI-INFLAMMATORY POTENTIAL OF MICONIA ALBICANS Sw. TRIANA (MELASTOMATACEAE) AND HEALTH BENEFITS OF MICONIA GENUS”
PALAVRAS-CHAVES: Miconia albicans, therapeutic mechanism, cytokines, antioxidant, arthritic, anti- inflammatory
PÁGINAS: 112
GRANDE ÁREA: Ciências da Saúde
ÁREA: Enfermagem
RESUMO:

This study reviews existing research on the therapeutic potential and molecularmechanisms of the Miconia genus, a group of medicinal plants with 282 species in Brazil andother tropical American nations. The research focuses on the pharmacological properties ofphytochemicals in the Miconia genus and their impact on well-being, while addressing safetyconsiderations. The study conducted literature searches across electronic databases andidentified 14 species from the genus Miconia, with the most frequently used species beingMiconia albicans Sw. Triana and Miconia rubiginosa (Bonpl.) DC. M. albicans showedsignificant efficacy and potential for developing safe drugs to treat pain and inflammation.Another study aimed to identify the anti-arthritic and anti-inflammatory profile of M.albicans ethanolic leaf extract (EEMA), which was found to have 23 compounds. The EEMAsignificantly decreased tumour necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β)levels in pleural lavage, lowered mechanical hyperalgesia, nociceptive and hyperalgesicbehaviors, and enhanced mobility. In the open-field test, EEMA significantly improved gripstrength and decreased the dimension of complete Freund's adjuvant (CFA)-inducedipsilateral knee edema. In conclusion, the Miconia genus's rich history in folk medicine,diverse therapeutic potential, and associated molecular mechanisms highlight its promise as asource for safe and effective treatments for pain and inflammation.

MEMBROS DA BANCA:
Interno - 3573579 - ANDRÉ SALES BARRETO
Interno - 3571566 - JULLYANA DE SOUZA SIQUEIRA QUINTANS
Externo à Instituição - LUCIANO AUGUSTO DE ARAUJO RIBEIRO
Presidente - 1467719 - LUCINDO JOSE QUINTANS JUNIOR
Interno - 426673 - RICARDO QUEIROZ GURGEL