Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE: SATHIYABAMA RAJIV GANDHI
DATA: 28/09/2023
HORA: 08:00
LOCAL: PLATAFORMA DE REUNIÃO REMOTA (meet.google.com/asx-fpwi-ith)
TÍTULO: “PHYTOCHEMICAL, ANTI- HYPERALGESIC AND ANTI-INFLAMMATORY POTENTIAL OF MICONIA ALBICANS Sw. TRIANA (MELASTOMATACEAE) AND HEALTH BENEFITS OF MICONIA GENUS”
PALAVRAS-CHAVES: Miconia albicans, therapeutic mechanism, cytokines, antioxidant, arthritic, anti- inflammatory
PÁGINAS: 112
GRANDE ÁREA: Ciências da Saúde
ÁREA: Enfermagem
RESUMO:

The Miconia genus, comprising 282 species in this region, has a rich history in Brazilian folkmedicine and other tropical American nations. It represents a diverse group of medicinalplants with various therapeutic applications, including pain relief, treatment of inflammatoryconditions, and addressing rheumatoid arthritis (RA). This study comprehensively reviewsexisting in vivo and in vitro investigations focused on the therapeutic potential and relatedmolecular mechanisms of the Miconia genus. The analysis assesses the pharmacologicalproperties of phytochemicals and their impact on well-being, while also addressing safetyconsiderations associated with the genus. We conducted literature searches across prominentelectronic databases, namely PubMed, Embase, Scopus, and Web of Science. Our search waslimited to Medical Subjects Headings (MeSH) and Descriptores en Ciencias de la Salud(DCS) to identify studies published up until December 2022. We employed keywords such as‘Miconia’, ‘biological activities’, ‘therapeutic mechanisms’, ‘animal model’, ‘cell-linemodel’, ‘antinociceptive’, ‘hyperalgesia’, ‘anti-inflammatory’, and ‘inflammation’ to gatherpertinent information about the genus. In 18 in vitro experiments, the therapeutic potentialsand mechanisms of action of 14 species from the genus Miconia were investigated. In eight invivo studies, they evaluated their analgesic, antioxidant, antinociceptive, and anti-osteoarthritis activities as well as their anti-inflammatory, anticancer, analgesic, antibacterial,cytotoxic, mutagenic, antioxidant, anti-leishmanial, and anti-osteoarthritis potentials. Some ofthe main related molecular mechanisms identified are the modulation of cytokines such as IL-1β, IL-6, and TNF-α, as well as the inhibition of inflammatory mediators and prostaglandinsynthesis. The limited number of studies demonstrated that commonly available species fromthe genus Miconia are safe for consumption. Miconia albicans Sw. Triana and Miconiarubiginosa (Bonpl.) DC., were the most frequently used species and showed significantefficacy and potential for developing safe drugs to treat pain and inflammation.
8In our another study due to some gaps in information about the plant species, we aimed toidentify the anti-arthritic and anti-inflammatory profile of M. albicans ethanolic leaf extract(EEMA), as well as to carry out dereplication and quantification using HPLC-DAD-ESI-/MS/MS. 23 compounds were discovered by HPLC-DAD-ESI-MS/MS analysis, withglycoside flavonoids primarily generated from quercetin and rutin serving as the primaryconstituents. In the pleurisy model, EEMA significantly decreased TNF-α and IL-1β levels inpleural lavage by ELISA approach. EEMA also markedly lowered mechanical hyperalgesiaand nociceptive and hyperalgesic behaviours, determined by the rearing test. In the open-fieldtest, EEMA significantly enhanced mobility. EEMA considerably improved the grip strengthof the back paw. EEMA significantly decreased the dimension of complete Freund's adjuvant(CFA)-induced ipsilateral knee edema. In conclusion, the Miconia genus's rich history in folk medicine, diverse therapeuticpotential, and associated molecular mechanisms highlight its promise as a source for safe andeffective treatments for pain and inflammation, with M. albicans standing out due its abilityto modulate crucial pro-inflammatory cytokines, mitigate the inflammatory process, andsubsequently alleviate key arthritis symptoms, stands as a noteworthy finding.

MEMBROS DA BANCA:
Interno - 3573579 - ANDRÉ SALES BARRETO
Externo à Instituição - IRWIN ROSE ALENCAR DE MENEZES
Externo à Instituição - LUCIANO AUGUSTO DE ARAUJO RIBEIRO